Volume 13, Issue 3 (2024)
JCP 2024, 13(3): 215-223 |
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Abbod M, Safaie N, Gholivand K, Ayyari M. Potential of new fungicide production from phthalides of Kelussia odoratissima. JCP 2024; 13 (3) :215-223
URL: http://jcp.modares.ac.ir/article-3-53562-en.html
URL: http://jcp.modares.ac.ir/article-3-53562-en.html
1- Department of Plant Pathology, Faculty of Agriculture, Tarbiat Modares University, Tehran, Iran. & Department of Plant Protection, Faculty of Agriculture, Al-Baath University, Homs, Syria.
2- Department of Plant Pathology, Faculty of Agriculture, Tarbiat Modares University, Tehran, Iran. ,nsafaie@modares.ac.ir
3- Department of Chemistry, Faculty of Science, Tarbiat Modares University, Tehran, Iran.
4- Department of Horticultural Science, Faculty of Agriculture, Tarbiat Modares University, Tehran, Iran.
2- Department of Plant Pathology, Faculty of Agriculture, Tarbiat Modares University, Tehran, Iran. ,
3- Department of Chemistry, Faculty of Science, Tarbiat Modares University, Tehran, Iran.
4- Department of Horticultural Science, Faculty of Agriculture, Tarbiat Modares University, Tehran, Iran.
Abstract: (53 Views)
A bioassay-guided fractionation on repeated silica gel column chromatography was used to identify natural antifungal agents in the ethanol extract of Kelussia odoratissima leaves. The ethyl acetate fraction of the extract has significant inhibitory activity against Macrophomina phaseolina (Tassi) Goid, whereas the water fraction showed no effect. The main compound responsible for antifungal activity was determined by NMR and Mass Spectrometry techniques and identified as (Z)-3-butylidenephthalide. It exhibited the highest mycelial growth inhibition with IC50 = 270 mg/L. Additionally, it inhibited the microsclerotia production and dark pigments formation. (Z)-ligustilide was identified as a moderately active compound with 62% inhibition. These findings revealed the crucial role of natural phthalides as sources of bioactive compounds that might be used in natural pesticide discovery.
Keywords: Macrophomina phaseolina, (Z)-3-butylidenephthalide, (Z)-ligustilide, natural products, Lead compound
Article Type: Original Research |
Subject:
Plant Disease Management
Received: 2021/06/25 | Accepted: 2024/12/15 | Published: 2024/12/16
Received: 2021/06/25 | Accepted: 2024/12/15 | Published: 2024/12/16
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